Robert Boyle wrote and published "The Sceptical Chymist: or Chymico-Physical Doubts & Paradoxes" in 1661. Sir Isaac Newton wrote many works but could be best remembered for "The Principia: Mathematical Principles of Natural Philosophy" in 1726. Both of these works could be considered the beginning of the scientific revolution (though I do not believe that either Boyle or Newton would want "revolution" term used in later discoveries as a result of their work.)
